Keyboard shortcuts are one of those little things that just make your life easier. Below are the ones I use on a daily basis, the most basic and useful essentials of navigating in a Windows environment. You may know some or most of these already, but then, you may find some new ones, too.
- Ctrl+C – Copy.
- Ctrl+X – Cut.
- Ctrl+V – Paste.
- Ctrl+S – Save file.
- Ctrl+N – Create new file.
- Ctrl+B – Turn bold on/off (in most text editing programs).
- Ctrl+I – Turn italics on/off (in most text editing programs).
- Ctrl+U – Turn underline on/off (in most text editing programs).
- Ctrl+A – Select all.
- Tab – Move to the next field in a form.
- Shift+Tab – Move to the previous field in a form.
- Ctrl+Z – Undo.
- Ctrl+Y – Redo (does not work in as many programs as Ctrl+Z).
- Windows Key + D – Show desktop.
- Windows Key + L – Lock computer.
- Ctrl+Alt+Delete – The classic. Allows you (hopefully) to end a program that’s locked up.
- Hold Alt and press Tab repeatedly – Cycle through all open windows.
- Home – Move to the beginning of the line. A very basic but underused function.
- End – Move to the end of the line.
- Ctrl+Home – Move to the beginning of the document.
- Ctrl+End – Move to the end of the document.
- Shift+Arrow Key – Highlight text.
- Shift+Delete – Delete a file without putting it in the Recycle Bin. (Use with caution.)
- Ctrl+T – In an Internet browser, open a new tab.
- Ctrl+F – Search for text in a document.
- Shift+Enter – In many programs (like some instant messengers), hitting “Enter” performs a command (like sending the message) instead of adding a new line. If all you want is a new line, Shift+Enter is the way to go.
- Print Screen – Another very useful key that’s often overlooked. Take a screenshot of the current screen and copy it. You can then paste it into any graphical editor (like MS Paint).
- Alt+Print Screen – Take a screenshot of just the window that’s currently active.
Those are the ones I can remember off the top of my head, but I’m sure I missed plenty of good ones. If I left out any of your favorites, how about sharing them in the comments?

Most of mine wouldn’t make any sense. I create custom hot keys for my IDE and make heavy use of AutoHotKey.
You’ve got me curious. What’s your IDE of choice?
I know that this is technically a mouse shortcut but clicking a link with the middle (roller) button opens it in a new tab.
Sweet! Had never heard that one, but I love it. Thanks Zeev!
One of my favourites is Ctrl+L, which in non-IE browsers puts the cursor in the address bar.
Another new one for me. Very cool, thanks Nazaniel!